2012 Defensive Leaders
| Season | Stats |
| Rank | Player | Team | GP | Tkl | Ast | Total | Sack | Yds | PD | Int | Yds | TD | FF | FR | Yds | TD | Sfty |
| 101. | Kyle Arrington, CB | NEP | 15 | 54 | 9 | 63 | 0 | 0 | 11 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 102. | Keenan Lewis, CB | NOS | 16 | 54 | 15 | 69 | 0 | 0 | 23 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 103. | Dashon Goldson, S | TBB | 16 | 53 | 14 | 67 | 0 | 0 | 10 | 3 | 21 | 0 | 1 | 2 | 71 | 0 | 0 |
| 104. | Jairus Byrd, S | BUF | 16 | 53 | 23 | 76 | 0 | 0 | 6 | 5 | 110 | 0 | 4 | 2 | 0 | 0 | 0 |
| 105. | Reggie Nelson, S | CIN | 13 | 53 | 29 | 82 | 1 | 8 | 9 | 3 | 10 | 0 | 1 | 0 | 0 | 0 | 0 |
| 106. | Kelvin Sheppard, LB | IND | 15 | 53 | 24 | 77 | 2 | 17 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 107. | Justin Houston, LB | KCC | 16 | 53 | 13 | 66 | 10 | 69 | 5 | 1 | 32 | 0 | 1 | 1 | 4 | 0 | 1 |
| 108. | Sean Smith, CB | KCC | 15 | 53 | 6 | 59 | 0 | 0 | 12 | 2 | 31 | 0 | 3 | 0 | 0 | 0 | 0 |
| 109. | Richard Sherman, CB | SEA | 16 | 53 | 10 | 63 | 1 | 16 | 24 | 8 | 57 | 1 | 3 | 1 | 0 | 0 | 0 |
| 110. | Johnathan Joseph, CB | HOU | 14 | 53 | 5 | 58 | 0 | 0 | 11 | 2 | 88 | 1 | 0 | 0 | 0 | 0 | 0 |
| 111. | Terence Newman, CB | CIN | 14 | 52 | 21 | 73 | 0 | 0 | 10 | 2 | 0 | 0 | 1 | 2 | 8 | 0 | 0 |
| 112. | Patrick Robinson, CB | NOS | 16 | 52 | 11 | 63 | 1 | 9 | 18 | 3 | 99 | 1 | 1 | 0 | 0 | 0 | 0 |
| 113. | Tramon Williams, CB | GBP | 16 | 52 | 9 | 61 | 0 | 0 | 15 | 2 | 38 | 0 | 0 | 0 | 0 | 0 | 0 |
| 114. | Patrick Peterson, CB | ARI | 16 | 52 | 3 | 55 | 0 | 0 | 17 | 7 | 64 | 0 | 0 | 1 | 60 | 0 | 0 |
| 115. | Javier Arenas, CB | ARI | 16 | 52 | 7 | 59 | 0 | 0 | 8 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 116. | Major Wright, S | CHI | 16 | 52 | 19 | 71 | 0 | 0 | 8 | 4 | 45 | 1 | 1 | 2 | 0 | 0 | 0 |
| 117. | Corey Webster, CB | NYG | 16 | 52 | 6 | 58 | 0 | 0 | 13 | 4 | 45 | 0 | 0 | 0 | 0 | 0 | 0 |
| 118. | Chris Harris, CB | DEN | 15 | 51 | 10 | 61 | 2.5 | 18 | 12 | 3 | 144 | 2 | 0 | 0 | 0 | 0 | 0 |
| 119. | Chris Conte, S | CHI | 15 | 51 | 16 | 67 | 0 | 0 | 9 | 2 | 70 | 0 | 0 | 1 | 0 | 0 | 0 |
| 120. | Stephon Gilmore, DB | BUF | 16 | 51 | 9 | 60 | 0 | 0 | 16 | 1 | 23 | 0 | 2 | 0 | 0 | 0 | 0 |
| 121. | Bruce Carter, LB | DAL | 11 | 51 | 19 | 70 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 122. | Erin Henderson, LB | MIN | 14 | 50 | 29 | 79 | 3 | 22 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 123. | Nick Roach, LB | OAK | 16 | 50 | 15 | 65 | 1.5 | 11 | 4 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 124. | Carlos Rogers, CB | SFO | 15 | 50 | 6 | 56 | 1 | 7 | 7 | 1 | 63 | 0 | 0 | 3 | 63 | 1 | 0 |
| 125. | Donald Butler, LB | SDC | 12 | 50 | 27 | 77 | 3 | 13 | 4 | 1 | 21 | 1 | 1 | 0 | 0 | 0 | 0 |
| 126. | Tarell Brown, CB | SFO | 15 | 50 | 5 | 55 | 0 | 0 | 13 | 2 | 17 | 0 | 0 | 0 | 0 | 0 | 0 |
| 127. | Josh Norman, CB | CAR | 15 | 50 | 21 | 71 | 0 | 0 | 7 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| 128. | Calais Campbell, DE | ARI | 13 | 50 | 13 | 63 | 6.5 | 28 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 129. | T.J. Ward, DB | CLE | 14 | 50 | 18 | 68 | 1 | 10 | 4 | 1 | 37 | 0 | 3 | 0 | 0 | 0 | 0 |
| 130. | Aldon Smith, LB | SFO | 16 | 49 | 16 | 65 | 19.5 | 145 | 1 | 1 | 6 | 0 | 3 | 0 | 0 | 0 | 0 |
| 131. | Ed Reed, FS | HOU | 15 | 49 | 9 | 58 | 0 | 0 | 15 | 4 | 78 | 1 | 0 | 3 | 30 | 0 | 0 |
| 132. | James Harrison, LB | CIN | 12 | 49 | 21 | 70 | 6 | 26 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 133. | Josh Robinson, CB | MIN | 15 | 49 | 3 | 52 | 0 | 0 | 3 | 2 | 68 | 0 | 0 | 0 | 0 | 0 | 0 |
| 134. | Joselio Hanson, CB | OAK | 15 | 48 | 12 | 60 | 0 | 0 | 5 | 2 | 24 | 0 | 1 | 2 | 1 | 0 | 0 |
| 135. | Brandon Carr, CB | DAL | 16 | 48 | 5 | 53 | 0 | 0 | 11 | 3 | 120 | 1 | 0 | 0 | 0 | 0 | 0 |
| 136. | Robert McClain, CB | ATL | 14 | 48 | 7 | 55 | 0 | 0 | 10 | 1 | 32 | 0 | 0 | 2 | 28 | 0 | 0 |
| 137. | Lamarr Houston, DE | OAK | 16 | 48 | 19 | 67 | 4.5 | 37 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 138. | Jamarca Sanford, S | MIN | 15 | 47 | 14 | 61 | 0 | 0 | 5 | 0 | 0 | 0 | 4 | 1 | 0 | 0 | 0 |
| 139. | Koa Misi, LB | MIA | 14 | 47 | 13 | 60 | 3.5 | 16 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 140. | Nnamdi Asomugha, CB | SFO | 16 | 47 | 8 | 55 | 0 | 0 | 12 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 141. | Justin Smith, DE | SFO | 14 | 47 | 18 | 65 | 3 | 23 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| 142. | Captain Munnerlyn, CB | CAR | 16 | 46 | 13 | 59 | 0 | 0 | 9 | 2 | 107 | 2 | 0 | 0 | 0 | 0 | 0 |
| 143. | Marcus Gilchrist, CB | SDC | 16 | 46 | 9 | 55 | 1 | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 144. | Vontae Davis, CB | IND | 10 | 46 | 5 | 51 | 1 | 3 | 8 | 3 | 26 | 0 | 0 | 0 | 0 | 0 | 0 |
| 145. | Kareem Jackson, DB | HOU | 15 | 45 | 6 | 51 | 0 | 0 | 16 | 4 | 71 | 1 | 0 | 0 | 0 | 0 | 0 |
| 146. | Prince Amukamara, CB | NYG | 12 | 45 | 8 | 53 | 0 | 0 | 7 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 147. | William Gay, CB | PIT | 15 | 45 | 12 | 57 | 1 | 9 | 6 | 2 | 7 | 0 | 3 | 1 | 0 | 0 | 0 |
| 148. | Charles Godfrey, S | CAR | 15 | 44 | 25 | 69 | 0 | 0 | 6 | 2 | 9 | 1 | 0 | 1 | 0 | 0 | 0 |
| 149. | Chris Houston, CB | DET | 14 | 44 | 11 | 55 | 0 | 0 | 11 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 0 |
| 150. | Bryan Scott, S | BUF | 16 | 44 | 19 | 63 | 0 | 0 | 8 | 4 | 66 | 1 | 1 | 2 | 8 | 0 | 0 |
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