2012 Defensive Leaders
| Season | Stats |
| Rank | Player | Team | GP | Tkl | Ast | Total | Sack | Yds | PD | Int | Yds | TD | FF | FR | Yds | TD | Sfty |
| 51. | Antonio Smith, DE | HOU | 15 | 24 | 7 | 31 | 7 | 51 | 3 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 52. | Glover Quin, SS | DET | 16 | 65 | 20 | 85 | 1 | 8 | 14 | 2 | 22 | 0 | 2 | 0 | 0 | 0 | 0 |
| 53. | Henry Melton, DL | CHI | 13 | 31 | 12 | 43 | 6 | 50 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 54. | Mike Adams, S | DEN | 16 | 60 | 20 | 80 | 1 | 2 | 12 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 |
| 55. | Stevie Brown, S | NYG | 16 | 56 | 10 | 66 | 0 | 0 | 11 | 8 | 307 | 0 | 2 | 1 | 9 | 0 | 0 |
| 56. | Ryan Kerrigan, LB | WAS | 16 | 42 | 12 | 54 | 8.5 | 52 | 8 | 1 | 28 | 1 | 2 | 1 | 0 | 0 | 0 |
| 57. | Curtis Lofton, LB | NOS | 16 | 82 | 41 | 123 | 1 | 12 | 7 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 |
| 58. | Terrance Knighton, DT | DEN | 14 | 20 | 12 | 32 | 2 | 12 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 59. | E.J. Biggers, CB | WAS | 13 | 39 | 9 | 48 | 1 | 8 | 7 | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 60. | Jeremy Mincey, DL | JAX | 16 | 35 | 6 | 41 | 3 | 19 | 5 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 61. | Shaun Phillips, LB | DEN | 16 | 33 | 17 | 50 | 9.5 | 64 | 3 | 0 | 0 | 0 | 2 | 3 | 0 | 1 | 0 |
| 62. | Cliff Avril, DE | SEA | 15 | 28 | 7 | 35 | 9.5 | 61 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 63. | Nick Fairley, DT | DET | 11 | 26 | 8 | 34 | 5.5 | 38 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 64. | Anthony Spencer, DE | DAL | 14 | 55 | 40 | 95 | 11 | 83 | 3 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 65. | Sam Acho, LB | ARI | 16 | 32 | 12 | 44 | 4 | 18 | 3 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 0 |
| 66. | Thomas Davis, LB | CAR | 15 | 66 | 35 | 101 | 0 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | -2 | 0 | 0 |
| 67. | Chris Houston, CB | DET | 14 | 44 | 11 | 55 | 0 | 0 | 11 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 0 |
| 68. | Jurrell Casey, DT | TEN | 15 | 34 | 20 | 54 | 3 | 31 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 69. | Michael Griffin, S | TEN | 16 | 59 | 19 | 78 | 1 | 8 | 4 | 4 | 59 | 0 | 2 | 0 | 0 | 0 | 0 |
| 70. | Eric Weddle, FS | SDC | 16 | 83 | 14 | 97 | 1 | 0 | 9 | 3 | 52 | 1 | 2 | 0 | 0 | 0 | 0 |
| 71. | Brandon Deaderick, DE | JAX | 10 | 10 | 8 | 18 | 1 | 7 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 72. | Philip Wheeler, LB | MIA | 16 | 78 | 31 | 109 | 3 | 30 | 6 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 73. | Reshad Jones, S | MIA | 16 | 74 | 21 | 95 | 1 | 5 | 9 | 4 | 28 | 0 | 2 | 2 | 24 | 0 | 0 |
| 74. | Larry Foote, LB | PIT | 16 | 75 | 38 | 113 | 4 | 29 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 |
| 75. | Stephon Gilmore, DB | BUF | 16 | 51 | 9 | 60 | 0 | 0 | 16 | 1 | 23 | 0 | 2 | 0 | 0 | 0 | 0 |
| 76. | William Moore, S | ATL | 12 | 60 | 16 | 76 | 1 | 13 | 8 | 4 | 51 | 0 | 2 | 1 | 0 | 0 | 0 |
| 77. | Ryan Clark, FS | PIT | 15 | 74 | 28 | 102 | 0 | 0 | 7 | 2 | 26 | 0 | 2 | 1 | 2 | 0 | 0 |
| 78. | Corey Wootton, DE | CHI | 15 | 20 | 7 | 27 | 7 | 42 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 79. | Mike DeVito, DE | KCC | 14 | 27 | 25 | 52 | 1 | 8 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 80. | Whitney Mercilus, LB | HOU | 14 | 15 | 3 | 18 | 6 | 17 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 81. | Ahtyba Rubin, DL | CLE | 13 | 30 | 14 | 44 | 2 | 13 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 82. | Paul Posluszny, LB | JAX | 16 | 106 | 33 | 139 | 2 | 10 | 7 | 3 | 20 | 0 | 2 | 0 | 0 | 0 | 0 |
| 83. | Kaluka Maiava, LB | OAK | 15 | 30 | 18 | 48 | 2 | 10 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 84. | Lance Briggs, LB | CHI | 16 | 73 | 29 | 102 | 1.5 | 8 | 11 | 2 | 110 | 2 | 2 | 0 | 0 | 0 | 0 |
| 85. | Patrick Willis, LB | SFO | 16 | 88 | 32 | 120 | 0.5 | 5 | 9 | 2 | 2 | 0 | 2 | 1 | 3 | 0 | 0 |
| 86. | Ahmad Brooks, LB | SFO | 16 | 35 | 12 | 47 | 6.5 | 50 | 6 | 1 | 50 | 1 | 2 | 0 | 0 | 0 | 0 |
| 87. | Major Wright, S | CHI | 16 | 52 | 19 | 71 | 0 | 0 | 8 | 4 | 45 | 1 | 1 | 2 | 0 | 0 | 0 |
| 88. | Adam Jones, CB | CIN | 15 | 32 | 5 | 37 | 1 | 6 | 9 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 89. | Kam Chancellor, SS | SEA | 16 | 69 | 22 | 91 | 0 | 0 | 4 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 90. | Stephen Tulloch, LB | DET | 16 | 74 | 38 | 112 | 0.5 | 5 | 6 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 0 |
| 91. | Brian Orakpo, LB | WAS | 2 | 5 | 0 | 5 | 1 | 2 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 92. | Manny Lawson, LB | BUF | 15 | 29 | 9 | 38 | 2 | 16 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 93. | Trent Cole, DE | PHI | 16 | 24 | 16 | 40 | 3 | 20 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 94. | Paul Kruger, LB | CLE | 15 | 30 | 12 | 42 | 9 | 47 | 6 | 1 | 0 | 0 | 1 | 1 | 9 | 0 | 0 |
| 95. | Tamba Hali, LB | KCC | 15 | 43 | 8 | 51 | 9 | 57 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 96. | Kurt Coleman, FS | PHI | 14 | 67 | 22 | 89 | 0 | 0 | 4 | 2 | 13 | 0 | 1 | 0 | 0 | 0 | 0 |
| 97. | Mark Barron, S | TBB | 16 | 72 | 17 | 89 | 0 | 0 | 10 | 1 | 12 | 0 | 1 | 0 | 0 | 0 | 0 |
| 98. | Nolan Carroll, CB | MIA | 13 | 41 | 6 | 47 | 1 | 5 | 5 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 99. | Andre Branch, DE | JAX | 9 | 9 | 2 | 11 | 1 | 7 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 100. | Sterling Moore, CB | DAL | 11 | 18 | 4 | 22 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 14 | 0 | 0 |
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