2012 Defensive Leaders
| Season | Stats |
| Rank | Player | Team | GP | Tkl | Ast | Total | Sack | Yds | PD | Int | Yds | TD | FF | FR | Yds | TD | Sfty |
| 101. | Eugene Sims, DE | STL | 11 | 14 | 5 | 19 | 3 | 22 | 1 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 102. | Erin Henderson, LB | MIN | 14 | 50 | 29 | 79 | 3 | 22 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 103. | Rob Jackson, LB | WAS | 15 | 26 | 9 | 35 | 4.5 | 22 | 7 | 4 | 19 | 1 | 2 | 1 | 0 | 0 | 0 |
| 104. | Frostee Rucker, DE | ARI | 15 | 29 | 19 | 48 | 4 | 22 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 105. | Dont'a Hightower, LB | NEP | 14 | 43 | 17 | 60 | 4 | 21 | 3 | 0 | 0 | 0 | 0 | 2 | 6 | 1 | 0 |
| 106. | Frank Alexander, DE | CAR | 13 | 10 | 8 | 18 | 2.5 | 21 | 3 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
| 107. | LaMarr Woodley, LB | PIT | 11 | 27 | 11 | 38 | 4 | 21 | 1 | 1 | 11 | 0 | 1 | 1 | 0 | 0 | 0 |
| 108. | Randy Starks, DE | MIA | 14 | 18 | 9 | 27 | 4.5 | 21 | 4 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| 109. | Olivier Vernon, DE | MIA | 14 | 18 | 5 | 23 | 3.5 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 110. | Jermaine Cunningham, LB | NEP | 12 | 16 | 8 | 24 | 2.5 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
| 111. | Stephen Nicholas, LB | ATL | 15 | 71 | 24 | 95 | 2 | 20 | 4 | 1 | 3 | 0 | 1 | 1 | 0 | 0 | 0 |
| 112. | Adrian Wilson, S | NEP | 15 | 39 | 15 | 54 | 3 | 20 | 5 | 1 | -2 | 0 | 1 | 0 | 0 | 0 | 0 |
| 113. | Trent Cole, DE | PHI | 16 | 24 | 16 | 40 | 3 | 20 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 114. | Tom Johnson, DT | NOS | 14 | 19 | 10 | 29 | 2 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 115. | Kevin Williams, DT | MIN | 16 | 20 | 11 | 31 | 2 | 20 | 7 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
| 116. | Brett Keisel, DE | PIT | 15 | 26 | 20 | 46 | 4.5 | 20 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| 117. | Vance Walker, DT | OAK | 15 | 21 | 11 | 32 | 3 | 20 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 118. | Kyle Moore, DE | CHI | 11 | 14 | 10 | 24 | 3 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 119. | Karl Klug, DT | TEN | 6 | 4 | 3 | 7 | 3.5 | 20 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 120. | Fred Evans, DT | MIN | 11 | 15 | 8 | 23 | 2 | 19 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 121. | Chris Canty, DL | BAL | 9 | 20 | 5 | 25 | 3 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 122. | Jeremy Mincey, DL | JAX | 16 | 35 | 6 | 41 | 3 | 19 | 5 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 123. | Jerel Worthy, DE | GBP | 9 | 11 | 3 | 14 | 2.5 | 19 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 124. | Quentin Groves, LB | CLE | 13 | 34 | 7 | 41 | 4 | 19 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 125. | Chase Blackburn, LB | CAR | 15 | 61 | 33 | 94 | 3 | 19 | 6 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 126. | Desmond Bryant, DT | CLE | 14 | 24 | 12 | 36 | 3 | 19 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 127. | Michael Brockers, DT | STL | 11 | 20 | 11 | 31 | 4 | 19 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 128. | Lawrence Jackson, DE | MIN | 11 | 11 | 10 | 21 | 2.5 | 18 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 129. | Sam Acho, LB | ARI | 16 | 32 | 12 | 44 | 4 | 18 | 3 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | 0 |
| 130. | Chris Harris, CB | DEN | 15 | 51 | 10 | 61 | 2.5 | 18 | 12 | 3 | 144 | 2 | 0 | 0 | 0 | 0 | 0 |
| 131. | Robert Ayers, DE | DEN | 10 | 8 | 8 | 16 | 2 | 18 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 132. | Jerry Hughes, LB | BUF | 14 | 21 | 11 | 32 | 4 | 18 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 133. | Martez Wilson, LB | NOS | 12 | 9 | 4 | 13 | 3 | 18 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 134. | Barry Cofield, NT | WAS | 14 | 15 | 22 | 37 | 2.5 | 18 | 6 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 135. | Whitney Mercilus, LB | HOU | 14 | 15 | 3 | 18 | 6 | 17 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 136. | Jerrell Freeman, LB | IND | 16 | 90 | 55 | 145 | 2 | 17 | 2 | 1 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| 137. | John Hughes, DT | CLE | 13 | 18 | 16 | 34 | 3 | 17 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 138. | Mike Patterson, DT | NYG | 4 | 3 | 3 | 6 | 1 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 139. | Linval Joseph, DT | NYG | 16 | 33 | 26 | 59 | 4 | 17 | 0 | 0 | 0 | 0 | 1 | 2 | 16 | 0 | 0 |
| 140. | Lorenzo Alexander, LB | ARI | 14 | 17 | 9 | 26 | 2.5 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 0 | 0 |
| 141. | Kelvin Sheppard, LB | IND | 15 | 53 | 24 | 77 | 2 | 17 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 142. | Ricky Jean-Francois, DT | IND | 8 | 12 | 10 | 22 | 2 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 143. | Koa Misi, LB | MIA | 14 | 47 | 13 | 60 | 3.5 | 16 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 144. | Manny Lawson, LB | BUF | 15 | 29 | 9 | 38 | 2 | 16 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 145. | Kroy Biermann, DE | ATL | 16 | 31 | 15 | 46 | 4 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 146. | Jonathan Babineaux, DT | ATL | 15 | 25 | 6 | 31 | 3.5 | 16 | 5 | 1 | -2 | 0 | 1 | 1 | 15 | 1 | 0 |
| 147. | Ray McDonald, DT | SFO | 14 | 28 | 10 | 38 | 2.5 | 16 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
| 148. | Richard Sherman, CB | SEA | 16 | 53 | 10 | 63 | 1 | 16 | 24 | 8 | 57 | 1 | 3 | 1 | 0 | 0 | 0 |
| 149. | Robert Geathers, DE | CIN | 13 | 12 | 18 | 30 | 3 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 150. | Calvin Pace, LB | NYJ | 16 | 34 | 20 | 54 | 3 | 16 | 2 | 0 | 8 | 0 | 1 | 1 | 0 | 0 | 0 |
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