2012 Defensive Leaders
| Season | Stats |
| Rank | Player | Team | GP | Tkl | Ast | Total | Sack | Yds | PD | Int | Yds | TD | FF | FR | Yds | TD | Sfty |
| 101. | Matt Shaughnessy, DE | ARI | 13 | 25 | 6 | 31 | 3.5 | 30 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 102. | Koa Misi, LB | MIA | 14 | 47 | 13 | 60 | 3.5 | 16 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 103. | Perry Riley, LB | WAS | 16 | 70 | 55 | 125 | 3.5 | 24 | 7 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 104. | Olivier Vernon, DE | MIA | 14 | 18 | 5 | 23 | 3.5 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 105. | Chase Blackburn, LB | CAR | 15 | 61 | 33 | 94 | 3 | 19 | 6 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 106. | John Hughes, DT | CLE | 13 | 18 | 16 | 34 | 3 | 17 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 107. | A.J. Hawk, LB | GBP | 16 | 81 | 39 | 120 | 3 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 108. | Adrian Wilson, S | NEP | 15 | 39 | 15 | 54 | 3 | 20 | 5 | 1 | -2 | 0 | 1 | 0 | 0 | 0 | 0 |
| 109. | Chris Canty, DL | BAL | 9 | 20 | 5 | 25 | 3 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 110. | Mathias Kiwanuka, LB | NYG | 14 | 22 | 9 | 31 | 3 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 111. | Sean Weatherspoon, LB | ATL | 13 | 70 | 25 | 95 | 3 | 10 | 4 | 1 | 6 | 0 | 1 | 1 | 0 | 0 | 0 |
| 112. | Donald Butler, LB | SDC | 12 | 50 | 27 | 77 | 3 | 13 | 4 | 1 | 21 | 1 | 1 | 0 | 0 | 0 | 0 |
| 113. | Erik Walden, LB | IND | 13 | 27 | 19 | 46 | 3 | 6 | 4 | 2 | 22 | 0 | 0 | 0 | 0 | 0 | 0 |
| 114. | Justin Francis, DL | NEP | 6 | 6 | 3 | 9 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 115. | Vance Walker, DT | OAK | 15 | 21 | 11 | 32 | 3 | 20 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 116. | Ziggy Hood, DE | PIT | 14 | 25 | 17 | 42 | 3 | 1 | 3 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 0 |
| 117. | Jeremy Mincey, DL | JAX | 16 | 35 | 6 | 41 | 3 | 19 | 5 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 118. | Connor Barwin, LB | PHI | 16 | 34 | 9 | 43 | 3 | 15 | 5 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
| 119. | Trent Cole, DE | PHI | 16 | 24 | 16 | 40 | 3 | 20 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 120. | Eugene Sims, DE | STL | 11 | 14 | 5 | 19 | 3 | 22 | 1 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| 121. | Robert Geathers, DE | CIN | 13 | 12 | 18 | 30 | 3 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 122. | Calvin Pace, LB | NYJ | 16 | 34 | 20 | 54 | 3 | 16 | 2 | 0 | 8 | 0 | 1 | 1 | 0 | 0 | 0 |
| 123. | London Fletcher, LB | WAS | 16 | 78 | 63 | 141 | 3 | 22 | 11 | 5 | 29 | 0 | 1 | 0 | 0 | 0 | 0 |
| 124. | Vince Wilfork, NT | NEP | 16 | 29 | 20 | 49 | 3 | 32 | 6 | 0 | 0 | 0 | 3 | 4 | 2 | 0 | 0 |
| 125. | Jason Jones, DE | DET | 10 | 7 | 3 | 10 | 3 | 15 | 4 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 0 |
| 126. | Erin Henderson, LB | MIN | 14 | 50 | 29 | 79 | 3 | 22 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 127. | Da'Quan Bowers, DE | TBB | 8 | 9 | 3 | 12 | 3 | 28 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 128. | Justin Smith, DE | SFO | 14 | 47 | 18 | 65 | 3 | 23 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| 129. | Kyle Moore, DE | CHI | 11 | 14 | 10 | 24 | 3 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 130. | Tyson Jackson, DE | KCC | 15 | 31 | 12 | 43 | 3 | 13 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 131. | Brandon Mebane, DT | SEA | 16 | 31 | 25 | 56 | 3 | 22 | 3 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
| 132. | Chad Greenway, LB | MIN | 16 | 96 | 50 | 146 | 3 | 14 | 4 | 1 | 3 | 0 | 0 | 2 | 0 | 0 | 0 |
| 133. | Mike Martin, DT | TEN | 15 | 21 | 15 | 36 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 134. | Antwan Barnes, LB | NYJ | 10 | 7 | 2 | 9 | 3 | 24 | 0 | 0 | 0 | 0 | 1 | 2 | 1 | 0 | 0 |
| 135. | Philip Wheeler, LB | MIA | 16 | 78 | 31 | 109 | 3 | 30 | 6 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 136. | Desmond Bryant, DT | CLE | 14 | 24 | 12 | 36 | 3 | 19 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 137. | Victor Butler, LB | NOS | 12 | 20 | 3 | 23 | 3 | 25 | 3 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 138. | Jerod Mayo, LB | NEP | 16 | 87 | 60 | 147 | 3 | 24 | 3 | 1 | 0 | 0 | 4 | 1 | 0 | 0 | 0 |
| 139. | Jurrell Casey, DT | TEN | 15 | 34 | 20 | 54 | 3 | 31 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 140. | David Harris, LB | NYJ | 16 | 79 | 44 | 123 | 3 | 16 | 3 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 141. | Martez Wilson, LB | NOS | 12 | 9 | 4 | 13 | 3 | 18 | 2 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
| 142. | Ray McDonald, DT | SFO | 14 | 28 | 10 | 38 | 2.5 | 16 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
| 143. | Chris Harris, CB | DEN | 15 | 51 | 10 | 61 | 2.5 | 18 | 12 | 3 | 144 | 2 | 0 | 0 | 0 | 0 | 0 |
| 144. | Lorenzo Alexander, LB | ARI | 14 | 17 | 9 | 26 | 2.5 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 7 | 0 | 0 |
| 145. | Shea McClellin, DE | CHI | 9 | 7 | 7 | 14 | 2.5 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 146. | Jermaine Cunningham, LB | NEP | 12 | 16 | 8 | 24 | 2.5 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
| 147. | C.J. Wilson, DE | GBP | 10 | 15 | 9 | 24 | 2.5 | 9 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 148. | Lawrence Jackson, DE | MIN | 11 | 11 | 10 | 21 | 2.5 | 18 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| 149. | C.J. Mosley, DL | DET | 15 | 36 | 9 | 45 | 2.5 | 27 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 |
| 150. | Frank Alexander, DE | CAR | 13 | 10 | 8 | 18 | 2.5 | 21 | 3 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
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