2012 Defensive Leaders
| Season | Stats |
| Rank | Player | Team | GP | Tkl | Ast | Total | Sack | Yds | PD | Int | Yds | TD | FF | FR | Yds | TD | Sfty |
| 1. | Charles Tillman, CB | CHI | 15 | 73 | 12 | 85 | 0 | 0 | 16 | 3 | 71 | 3 | 10 | 2 | 0 | 0 | 0 |
| 2. | Charles Johnson, DE | CAR | 16 | 31 | 11 | 42 | 12.5 | 100 | 4 | 0 | 0 | 0 | 7 | 1 | 0 | 0 | 0 |
| 3. | Elvis Dumervil, LB | BAL | 15 | 32 | 22 | 54 | 11 | 83 | 2 | 0 | 0 | 0 | 6 | 0 | 0 | 0 | 0 |
| 4. | Von Miller, LB | DEN | 16 | 55 | 13 | 68 | 18.5 | 130 | 2 | 1 | 26 | 1 | 6 | 0 | 0 | 0 | 0 |
| 5. | DeMarcus Ware, LB | DAL | 16 | 33 | 23 | 56 | 11.5 | 65 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 0 | 0 |
| 6. | Rob Ninkovich, DL | NEP | 15 | 32 | 26 | 58 | 8 | 51 | 1 | 0 | 0 | 0 | 5 | 4 | 3 | 0 | 0 |
| 7. | Jamarca Sanford, S | MIN | 15 | 47 | 14 | 61 | 0 | 0 | 5 | 0 | 0 | 0 | 4 | 1 | 0 | 0 | 0 |
| 8. | LaRon Landry, S | IND | 16 | 75 | 25 | 100 | 0 | 0 | 8 | 2 | 42 | 1 | 4 | 0 | 9 | 0 | 0 |
| 9. | Derrick Johnson, LB | KCC | 16 | 110 | 15 | 125 | 2 | 10 | 4 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
| 10. | Jerod Mayo, LB | NEP | 16 | 87 | 60 | 147 | 3 | 24 | 3 | 1 | 0 | 0 | 4 | 1 | 0 | 0 | 0 |
| 11. | Geno Atkins, DT | CIN | 15 | 39 | 15 | 54 | 12.5 | 90 | 2 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
| 12. | Carlos Dunlap, DE | CIN | 14 | 34 | 7 | 41 | 6 | 55 | 3 | 1 | 14 | 1 | 4 | 3 | 2 | 0 | 0 |
| 13. | Brandon Spikes, LB | NEP | 14 | 56 | 35 | 91 | 1 | 2 | 7 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 0 |
| 14. | J.J. Watt, DE | HOU | 16 | 69 | 12 | 81 | 20.5 | 139 | 16 | 0 | 0 | 0 | 4 | 2 | 7 | 0 | 0 |
| 15. | Jairus Byrd, S | BUF | 16 | 53 | 23 | 76 | 0 | 0 | 6 | 5 | 110 | 0 | 4 | 2 | 0 | 0 | 0 |
| 16. | Jason Babin, DE | JAX | 15 | 28 | 9 | 37 | 7 | 39 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 0 | 0 |
| 17. | Vince Wilfork, NT | NEP | 16 | 29 | 20 | 49 | 3 | 32 | 6 | 0 | 0 | 0 | 3 | 4 | 2 | 0 | 0 |
| 18. | Chase Blackburn, LB | CAR | 15 | 61 | 33 | 94 | 3 | 19 | 6 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 19. | Muhammad Wilkerson, DL | NYJ | 16 | 38 | 32 | 70 | 5 | 25 | 4 | 0 | 0 | 0 | 3 | 1 | 21 | 1 | 0 |
| 20. | Brian Robison, DE | MIN | 15 | 26 | 11 | 37 | 8.5 | 42 | 7 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 |
| 21. | Michael Bennett, DE | SEA | 16 | 34 | 7 | 41 | 9 | 57 | 2 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 22. | Brandon Browner, CB | SEA | 11 | 35 | 9 | 44 | 0 | 0 | 6 | 3 | 39 | 0 | 3 | 1 | 0 | 0 | 0 |
| 23. | Jasper Brinkley, LB | ARI | 16 | 62 | 35 | 97 | 0 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 24. | Richard Sherman, CB | SEA | 16 | 53 | 10 | 63 | 1 | 16 | 24 | 8 | 57 | 1 | 3 | 1 | 0 | 0 | 0 |
| 25. | Josh Wilson, DB | WAS | 16 | 54 | 20 | 74 | 1 | 12 | 13 | 2 | 8 | 0 | 3 | 2 | 30 | 1 | 0 |
| 26. | Danieal Manning, S | HOU | 16 | 59 | 18 | 77 | 1 | 0 | 8 | 2 | 59 | 1 | 3 | 1 | 1 | 0 | 0 |
| 27. | T.J. Ward, DB | CLE | 14 | 50 | 18 | 68 | 1 | 10 | 4 | 1 | 37 | 0 | 3 | 0 | 0 | 0 | 0 |
| 28. | Chris Clemons, DE | SEA | 15 | 31 | 9 | 40 | 11.5 | 87 | 4 | 0 | 0 | 0 | 3 | 1 | 0 | 0 | 0 |
| 29. | William Gay, CB | PIT | 15 | 45 | 12 | 57 | 1 | 9 | 6 | 2 | 7 | 0 | 3 | 1 | 0 | 0 | 0 |
| 30. | Cameron Wake, DE | MIA | 16 | 38 | 15 | 53 | 15 | 93 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 31. | Sean Smith, CB | KCC | 15 | 53 | 6 | 59 | 0 | 0 | 12 | 2 | 31 | 0 | 3 | 0 | 0 | 0 | 0 |
| 32. | Cameron Jordan, DE | NOS | 16 | 40 | 26 | 66 | 8 | 54 | 3 | 0 | 0 | 0 | 3 | 2 | 0 | 0 | 0 |
| 33. | Aldon Smith, LB | SFO | 16 | 49 | 16 | 65 | 19.5 | 145 | 1 | 1 | 6 | 0 | 3 | 0 | 0 | 0 | 0 |
| 34. | Cortez Allen, CB | PIT | 15 | 38 | 9 | 47 | 0 | 0 | 10 | 2 | 6 | 0 | 3 | 1 | 21 | 0 | 0 |
| 35. | Chandler Jones, DE | NEP | 13 | 24 | 21 | 45 | 6 | 33 | 5 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 |
| 36. | James Harrison, LB | CIN | 12 | 49 | 21 | 70 | 6 | 26 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 37. | Osi Umenyiora, DE | ATL | 16 | 27 | 15 | 42 | 6 | 36 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 38. | Greg Hardy, DE | CAR | 14 | 41 | 20 | 61 | 11 | 86 | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 39. | Steve Gregory, S | NEP | 11 | 31 | 6 | 37 | 0 | 0 | 5 | 3 | 50 | 0 | 2 | 2 | 30 | 1 | 0 |
| 40. | Donte Whitner, S | SFO | 16 | 61 | 21 | 82 | 0 | 0 | 5 | 1 | 42 | 1 | 2 | 1 | 0 | 0 | 0 |
| 41. | Antoine Cason, CB | ARI | 16 | 62 | 11 | 73 | 0 | 0 | 11 | 2 | 34 | 0 | 2 | 0 | 0 | 0 | 0 |
| 42. | Da'Norris Searcy, SS | BUF | 13 | 22 | 13 | 35 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 |
| 43. | Jo-Lonn Dunbar, LB | STL | 16 | 88 | 24 | 112 | 4.5 | 41 | 4 | 2 | 63 | 0 | 2 | 0 | 0 | 0 | 0 |
| 44. | Daryl Washington, LB | ARI | 16 | 108 | 26 | 134 | 9 | 51 | 2 | 1 | 7 | 0 | 2 | 1 | 3 | 0 | 0 |
| 45. | Mario Williams, DE | BUF | 16 | 37 | 9 | 46 | 10.5 | 51 | 4 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 0 |
| 46. | Rob Jackson, LB | WAS | 15 | 26 | 9 | 35 | 4.5 | 22 | 7 | 4 | 19 | 1 | 2 | 1 | 0 | 0 | 0 |
| 47. | Lawrence Timmons, LB | PIT | 16 | 75 | 31 | 106 | 6 | 51 | 5 | 3 | 80 | 1 | 2 | 1 | 1 | 0 | 0 |
| 48. | Morgan Burnett, S | GBP | 16 | 87 | 35 | 122 | 2 | 25 | 5 | 2 | 1 | 0 | 2 | 1 | 0 | 0 | 0 |
| 49. | Brandon Graham, DE | PHI | 13 | 30 | 8 | 38 | 5.5 | 33 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 |
| 50. | D'Qwell Jackson, LB | CLE | 16 | 63 | 51 | 114 | 3.5 | 5 | 7 | 2 | 31 | 1 | 2 | 2 | 0 | 0 | 0 |
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